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Several IL-15 SNPs which were associated with minimal residual disease (MRD) have been linked to enhanced IL-15 transcription/translation efficiency in vitro [37].
PI3K and Akt have been linked to enhanced cell survival through the phosphorylation and subsequent inhibition of the proapoptotic molecule Bad (Neshat et al, 2000).
BMPR2 mutations have been linked to enhanced cell apoptosis, inhibited cell proliferation and suppressed nitric oxide synthesis in human pulmonary microvascular ECs (Wang et al., 2014).
Moreover, the TGF-β-facilitated signaling along the MAPK axis exerts pro-proliferative and anti-apoptotic effects on the cell, while Ras/MAPK activity alone – without TGF-β induction - has also been linked to enhanced EMT [21 23].
For example, strong arousal often signifies the importance of an event or stimulus, and the arousal triggered by an experience has been linked to enhanced memory of that experience (Dolan, 2002; McGaugh, 2006; Sharot, Martorella, Delgado, & Phelps, 2007).
Melanization of mycelium has been linked to enhanced virulence in numerous plant and animal pathogenic fungi [33].
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In other systems, prolonged JNK activation has been linked to enhancing apoptosis [1].
The extent of diagenetic magnetite dissolution and authigenic formation of fine-grained greigite in these sapropels and their underlying dissolution intervals are linked to enhanced sulphidic conditions during sapropel formation.
In this model, we interpret cytokinesis failure and tetraploidy to be linked to enhanced cellular proliferation, not as a direct consequence of proliferation, but because both processes are induced by c-Myc activation and GpIbα overexpression.
For example, Ames Dwarf mice, which lack the pituitary hormones growth hormone, prolactin, and thyroid stimulating hormone and show extended lifespan compared to their wild-type counterparts, were found to exhibit upregulated transsulfuration and low homocysteine levels, which might be linked to enhanced cellular oxidative stress defense mechanisms [4], [5].
We have shown that primary tumor formation is linked to enhanced cell survival mechanisms exhibited by these cells [ 33].
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