Most of the embryonic and postembryonic lineages in the Drosophila VNC have previously been characterised and the primary clones have been linked to identified embryonic progenitors (Bossing and Technau, 1994; Bossing et al., 1996b; Schmid et al., 1999; Schmidt et al., 1997; Truman et al., 2004).
O-GlcNAc modified proteins including the polycomb group, p53, c-Myc, insulin receptor have been linked to the regulation of embryonic development [ 21], cancer [ 22, 23] and diabetes [ 24].
Several extracellular signals have been linked to the regulation of embryonic lung stem cells during development (Que et al, 2007; Lange et al, 2009; Morrisey and Hogan, 2010; Rock et al, 2011).
Membrane-associated Brk has recently been linked to oncogenic actions in human embryonic kidney (HEK -293 cells [ 2].
Polycomb receptor complex-2 (PRC2) occupancy of gene promoters by the components Suz12 and Eed has been linked to susceptibility to methylation in human embryonic stem cells [ 43].
In women, type I (insulin-dependent) diabetes has been linked to complications during pregnancy, often resulting in miscarriage, embryonic developmental abnormalities and congenital malformations [1].
This research is the first time, however, that splicing variety has been linked to the unprecedented developmental flexibility, or pluripotency, exhibited by embryonic stem cells.
Interestingly, the inappropriate reactivation of embryonic and developmental programs in adult tissues has been linked to the initiation and progression of human malignancies [ 3, 4].
Specifically, ectrodactyly has been linked to the ability of p63 to regulate transcription of Dlx5 and Dlx6, both in vitro and in the developing embryonic limbs (7).
There is evidence showing that nearly all of these are linked to the embryonic origin of interneurons and therefore are specified by genetic pathways.
