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Critically, impaired sleep is common among adolescents [34], and has been linked to deficient striatal recruitment during reward anticipation [35].
The DRD4 exon III variable number tandem repeat "7 repeats or longer" allele (DRD4 7R+) has been linked to deficient dopamine functioning [ 20, 21].
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These results collectively suggest that increased apoptosis, decreased Treg function and concomitant gene expression changes could be linked to deficient IL-2 secretion from effector T-cells.
This impairment is linked to deficient length-dependent regulation of myocardial function [ 13].
Additionally, mitochondrial metabolism has been linked to pathogenicity, as respiratory deficient strains were shown to be unable to form biofilms [ 68], lack virulence [ 71] or exhibit decreased pathogenicity [ 72] and increased sensitivity to oxidative stress induced by photodynamic therapy [ 73].
Frontal damage has been linked to neglect behaviours [2], [3], [19], deficient IOR behaviour [7] and perseveration [6].
Loss of Btk in macrophages and myeloid cells has been linked to compromised inflammatory responses, and Btk-deficient mast cells failed to produce cytokines following FcεRI stimulations.
Several of the pathological outcomes in ATM deficient mice have been linked to ROS and many of these pathologies can be reversed by the addition of antioxidants, highlighting the important role of ATM in regulating redox-homeostasis (Ito et al., 2004; Reliene and Schiestl, 2006, 2007; Reliene et al., 2008; Freund et al., 2011; Okuno et al., 2012; D'Souza et al., 2013).
Deficient resuscitation skills have been linked to students absorbing inaccurate techniques from television programs such as ER [ 14].
In contrast, aberrations of the apoptotic mechanisms that cause excessive or deficient programmed cell death have been linked to a wide array of pathologic conditions.
Fungal infections have been linked to IL-17 responses [ 4] and IL-17-deficient mice are more susceptible to infection with Candida albicans [ 30].
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