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Their dysregulation causes cell depolarization, loss of contact-dependent inhibition of proliferation, increased motility, leakiness of the mucosal barrier, and disturbances in enterocytic cell-cell contact formation – processes that have been linked to colorectal carcinogenesis [3] and inflammatory bowel disease [4] [6].
In contrast to BRAF, RAF1 (CRAF) has not been linked to colorectal cancer, but these results suggest that it might play a role in hypermutated tumors.
The IGF pathway has been linked to colorectal malignancy [ 32, 33], and serum levels of IGF1 have been associated with colon cancer risk [ 34].
Cigarette smoking and alcohol consumption are potentially modifiable lifestyle factors that have been linked to colorectal cancer risk in prospective studies of Western populations.
Furthermore, the top 25 of most differentially expressed genes includes two genes that have previously been linked to colorectal cancer: Mmp25[ 77] and WT1[ 78].
Potential exposure to PAHs from employment as a gas furnace worker [ 4], smoking [ 10], and reported meat consumption [ 5- 9] has been linked to colorectal cancer and colorectal adenoma.
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It has been reported that highly expression of B4GALT4 is linked to colorectal cancer metastasis and poor prognosis.
STG concentrations may be linked to colorectal cancer risk by bile acid excretion, circulation hormones, or energy supply to neoplastic cells (McKeown-Eyssen, 1994).
Alternatively, smoking may be linked to colorectal carcinogenesis by effects on the "traditional serrated pathway" via TSA precursor lesions that are typically located in the distal colorectum [ 29].
They know something is wrong but they don't… sometimes some people can't deal with it.' Such a response was particularly the case when patients wrongly assumed the request for a stool sample was linked to colorectal cancer screening.
Inherited defects in genes associated with DNA mismatch repair (MMR) have been linked to familial colorectal cancer.
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