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Several genetic disorders and complex diseases have been linked to altered nuclear architecture and function.
Obesity has recently been linked to altered dopaminergic fronto-striatal circuits, thus implying impairments in cognitive domains that rely on its integrity.
Furthermore, striatal dopamine changes have been linked to altered cortical function during cognitive tasks, in line with preclinical evidence that a circuit involving cortical projections to the striatum and midbrain may underlie the striatal dopamine changes.
The silencing effect of polycomb proteins has been linked to altered chromatin environment and Pol II stalling and, recently, it was proposed that a steric hindrance excluding Pol II elongation may mediate polycomb silencing [28].
57– 59 Mutations in pfatp4 have been linked to altered sensitivity to these candidate antimalarials.
EE has been linked to altered stress responses in some disorders, but ADHD has not been studied.
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Depression has been linked to altering the course of infection due to immune function impairment.
Most intriguing was the alteration in phosphatidylcholines, which can be linked to altered VLDL formation, which is a key factor in the pathogenesis of fatty liver disease.
Objective: Epidemiologic data suggest that the malignant transformation of ovarian epithelium may be linked to altered steroid hormone homeostasis.
NO synthetase expression and NO synthesis are linked to altered metabolism, neoplasticity, invasiveness, chemoresistance, immune evasion, and ultimately to poor prognosis of cancer patients.
Additionally, the transcriptional response was linked to altered T3 and T4 levels and to thyroid gland development at 0.32 and 32 Gy, 6 and 24 h after 211At administration, respectively.
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