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For reasons that are not yet entirely clear the pressure in some astronauts' brains appears to rise as a consequence of space flight, and this has been linked to alterations in their eyesight that sometimes persist for many years after their return to Earth.
Mood disorders and substance abuse disorders are risk factors for suicide and have also been linked to alterations of DNA methylation in several genes [24], [25], [36], [37].
Effects of ROS on cell morphology have been linked to alterations in Ras pathway modulating cell architecture related proteins such as Rac1 and actin-binding protein Rho1-cofilin [38].
Many virus-induced symptoms have been linked to alterations in plant hormone synthesis [ 4, 48, 49].
It is of interest that several pathologies have been linked to alterations in OPG and RANKL.
TS has been linked to alterations in inhibitory γ-aminobutyric acid (GABA) signaling [ 15, 16].
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Ground based timber harvesting on wet sites has been linked to alteration of soil properties that may result in reduced long term site productivity.
The decrease in NEP expression has been linked to alteration in Aβ clearance leading to Aβ accumulation, which is considered to be an important event contributing to the development and progression of AD [7].
Environmental exposures have been linked to alteration in the innate immune response as well, with studies conducted on pregnant rats showing that prenatal exposure to LPS leads to a suppressed innate immune response in offspring when examined at 5 days post birth [ 3] or even after 40 weeks of life [ 4].
Fig. 3 Aberrant epigenetic modifications are linked to alterations in the autophagy pathway in critically ill patient osteoclasts.
Reference: Jaremka, Lisa M., et al. "Attachment anxiety is linked to alterations in cortisol production and cellular immunity".
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