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High cellular ROS levels have been linked to ageing, human cancers, inflammatory, lung and cardiovascular diseases [5], [10].
Oxidative stress in tissues has been linked to ageing and degenerative diseases [ 9].
Mutations in POLG, the gene encoding the catalytic subunit, are among the most common causes of mitochondrial disease 1 and have been linked to ageing 2 and neurodegeneration.
Due to this lack of complete assembly, telomere evolution has not been fully characterized, though a great deal is to be gained from it, as telomeres have been linked to ageing (McEachern et al., 2000).
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A functional decline in tissue stem cells and mitochondrial dysfunction have each been linked to aging and multiple aging-associated pathologies.
Free radicals can damage DNA, cell membranes and the lining of arteries; not surprisingly, they've been linked to aging, cancer and heart disease.
Researchers have found that children who are physically abused and bullied tend to have shorter telomeres structures at the tips of chromosomes whose shrinkage has been linked to aging and disease.
Telomere function has been linked to aging.
Another fundamental cellular process that has been linked to aging is the gradual attrition of telomeres with increasing age [4].
Autophagy has been linked to aging, and a reduction in autophagy during aging has been observed in rodents and other organisms [34], [35].
Telomeres and telomerase, which have been linked to aging in other systems, have also been characterized in the medaka [18], [19], [20].
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