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Telomere loss has been linked to age and stress-induced premature senescence.
Osteoarthritis is the most common cause of shoulder arthropathy and has been linked to age [ 1] and chronic overuse [ 2].
Shorter telomeres have been linked to age related diseases, a higher mortality rate [ 6], and also to premature ageing syndromes like progeria or trichotiodystrophy [ 40, 41].
Mutations in hem-1 have been linked to age related macular degeneration (ARMD), indicating the importance of this protein in retinal function [ 8] and providing a new avenue for understanding ARMD, the main cause of blindness in the western world.
In large cohorts of patients undergoing cardiac surgery, post-CPB LV dysfunction has been linked to age, female gender, history of heart failure, recent myocardial infarct, low LV ejection fraction, prolonged aortic cross-clamping and complexity of surgery [ 7- 11].
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A functional decline in tissue stem cells and mitochondrial dysfunction have each been linked to aging and multiple aging-associated pathologies.
Free radicals can damage DNA, cell membranes and the lining of arteries; not surprisingly, they've been linked to aging, cancer and heart disease.
Both SIRT1 and mTOR have been linked to age-associated diseases with SIRT1 activation having a protective effect, whereas inhibition of mTOR conferring a beneficial effect.
Oxidation of proteins during aging or under conditions of oxidative stress may lead to alterations in protein structure and function and has been linked to age-related diseases [1], [2].
Telomere function has been linked to aging.
Another fundamental cellular process that has been linked to aging is the gradual attrition of telomeres with increasing age [4].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com