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Severe neuropathological changes leading to higher neurocognitive impairment have sometimes been linked to advanced immunosuppression either due to co-morbidity with other viral infections such as hepatitis C virus (HCV) [8], [9] or due to illicit drug abuse [10] [12].
Reduced access to healthcare has been linked to advanced stage of cancer [ 5, 7] and worse survival [ 6, 7].
Furthermore, aberrant promoter methylation of RASSF1, RARB, and DAPK1 have been linked to advanced NPC, characterized by advanced stage and positive lymph nodes [ 42].
High levels of circulating CRP have also been linked to advanced disease and a poor prognosis in various malignancies, including oral and esophageal SCC [ 6- 8], lung cancer [ 9, 10], melanoma [ 11], hepatocellular carcinoma [ 12, 13], breast cancer [ 14], endometrial cancer [ 15], renal cell carcinoma [ 16, 17], urothelial carcinoma [ 18], and castration-resistant prostate cancer [ 19, 28].
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The incidence of vulvar cancer has been linked to advancing age, but also appears in younger women [ 4].
Organizational aspects played a role in provision of advance care planning in community-based care management organizations [ 26]; in that study, amongst other things availability of training and resources was linked to advance care planning.
Humans have the most prominent eyes of any species with regard to determining direction of gaze [17], which has been linked to our advanced and perhaps unique social cognition abilities [18].
Moreover, planning well in advance has been linked to lower-stress vacations, which means that employees will be more likely to return feeling refreshed and ready to get back to work.
We do know that advanced paternal age, in rare instances, has been linked to some genetic disorders.
A new study by researchers at the University of East Anglia in England shows that individual birds migrate like clockwork, but nesting and hatching are happening earlier as a result of warmer temperatures, and this appears to be linked to the advancing of overall migration patterns.
Longer delays in initiation of treatment can also be linked to elaborate, highly advanced treatment regimens (e.g. time is needed to determine molecular markers).
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