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The sensing of larger protein digestion products simulated by, for example meat hydrolysate has been linked to activation of mitogen-activated protein (MAP) kinases, but the receptors involved are less clear [ 35,36].
76 Furthermore, p53 has been linked to activation of Fas and DR5/KILLER death receptors, which activate the extrinsic apoptosis pathway that also contributes to caspase-mediated cell death.
Hybridization has been linked to activation of transposable elements in several organismal groups, with most examples documenting such activity in early generation hybrid genotypes (Waugh O'Neill et al. 1998; Labrador et al. 1999; Shan et al. 2005; Petit et al. 2010).
Since postpartum psychosis has been linked to activation of the immune system, it has been hypothesized that infectious agents may be involved in the pathogenesis of this disorder.
EGFR expression has also been linked to activation of ErbB2 in human breast cancers [22].
Potassium efflux has been linked to activation of both NLRP3 and NLRP1 inflammasomes [32].
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AdipoR1 is ubiquitous, but is most abundantly expressed in skeletal muscle and is linked to activation of AMP-activated kinase (AMPK) pathways.
Direct effects are linked to activation of AMP-activated protein kinase (AMPK) and an inhibition of mammalian target of rapamycin mTOR signaling, and indirect effects are mediated by reductions in circulating insulin, leading to reduced insulin receptor (IR -mediated sIR -mediated
Therefore, we analysed whether PHD3 activity is linked to activation of caspase-3 and found that PHD3 overexpression increased caspase-3 activity.
Thus, AtHSFA2, AtHSFA4a, and AtHSFA7a may be linked to activation of different target genes/pathways in the HSR.
The pathogenesis of psoriasis is linked to activation of several types of leukocytes that control cellular immunity and to a T-cell-dependent inflammatory process in skin that accelerates the growth of epidermal and vascular cells in psoriasis lesions.
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