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Substrate reduction therapy (miglustat, [Zavesca®]; Actelion Pharmaceuticals, Allschwill, Switzerland) has also been licensed for type 1 Gaucher disease and may be used in adult patients with mild to moderate disease for whom enzyme replacement therapy is not a therapeutic option (EMEA, 2006).
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These analogues are licensed for type 2 diabetes, but their efficacy in patients with non-alcoholic steatohepatitis is unknown.
Botulinum toxin type A has been licensed for use in chronic migraine in some countries, based largely on two commercially sponsored trials.
13 18 Subsequently, it has been licensed for glycaemic control in overweight patients with type 2 diabetes (T2D).
Today, four DNA vaccines have been licensed for veterinary use.
Botulinum toxin type A (BOTOX) is licensed for the prophylaxis of headaches in adults with chronic migraine (CM).
Gemcitabine is licensed for use in a number of tumor types, including lung and pancreas cancers where KRAS mutations are common.
The phosphodiesterase type 5 inhibitors, which are licensed for the treatment of erectile dysfunction, have been evaluated for use in PE.
This genotype is considered to be consistent with the Boeringer-Ingelheim Ingelvac PRRS ATP™ vaccine type [ 8, 20, 25], which was licensed for use in Canada in 2000 [ 26].
Fulvestrant is the first of a new type of oestrogen receptor (ER) antagonist to be licensed for the treatment of advanced breast cancer [ 10, 11].
Effective prophylactic vaccines are available against human papillomavirus (HPV) types 6, 11, 16, and 18 which are licensed for routine use among young women.
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