Although previous studies have found automated percutaneous discectomy and epidural percutaneous discectomy to be less efficacious than conventional discectomy, these percutaneous procedures may be effective and cost-effective as a first surgical treatment for herniated lumbar disc.
Assuming that crystalloid solutions possess glycocalyx releasing properties per se, and given the fact that crystalloids were less efficacious than the colloids to restore blood pressure, we cannot exclude that the amount of heparan sulphate and syndecan-1 would have been higher in the RA group if resuscitation had been targeted to obtain similar blood pressures in all groups.
In the case of off-label medications, the assumption of equal efficacy with rectal diazepam was a conservative estimate as clinical experts in several countries suggested that other off-label medications, such as lorazepam tablets administered by the buccal route, were less efficacious than rectal diazepam.
In clinical trials, pharmacological inhibitors of PDE4 developed as potential therapies for treatment of inflammatory diseases were less efficacious than preclinical data suggested [18], [21], [22]; consequently, none has yet been approved for clinical use [23], [24].
Some results of such an exploration are shown in Table 2. Table 2 shows that increasing VMAT2 could elevate concentrations of extracellular dopamine and total dopamine, but is less efficacious than MAO inhibition.
Both deficient cell populations were less efficacious than wt MSCs in decreasing the paw swelling of the arthritic mice and wt MSCs were the only cell population able to significantly reduce the paw swelling of treated mice (Fig. 5A).
However, LMWC is less efficacious than metformin in vitro.
In general dopamine agonists are considered to be less efficacious than levodopa.
For each outcome category, the SP treatment was less efficacious than the AQ treatment.
These agents appear to be less efficacious than dopamine agonists, but are better tolerated.
