Sentence examples for been largely implicated from inspiring English sources

Despite their lack of protein coding potential, ncRNAs have been largely demonstrated to regulate the majority of biological processes and have also been largely implicated in cardiovascular disorders.

For instance, RANTES and IL-8 are elevated in plasma of obese individuals [ 31– 33] and have been largely implicated in obesity-related health complications [ 34– 36] as well as in the mechanisms of cancer progression [ 37– 37].

Processes such as cellular ageing, senescence and chondrocyte apoptosis have been largely implicated in the initiation and progression of cartilage degradation, which is characterised by mitochondrial dysfunction and depletion of cellular energy stores.

Tumor suppressor p53 has been largely implicated in the metabolic remodeling that cancer cells develop during progression, particularly through the regulation of mitochondrial respiration via TIGAR and COXIV of the respiratory chain [ 30].

A potential candidate for a transmembrane protein partner of the 500-kDa complex is the low-density lipoprotein (LDL) receptor related protein (LRP1), which is a large scavenger receptor mediating endocytosis of various biological components and is largely implicated in cytoskeleton organization [ 7, 62, 63].

But, in a study released earlier this year, a gene-hormone interaction that appears to be largely implicated was identified.

The plasminogen activation system is largely implicated in pathological angiogenic processes.

Gap junctions have also been shown to be largely implicated in the mediators- and endothelium-related relaxation [5], [30].

Local factors are largely implicated in inducing mammary involution [ 8– 10].

MMP-2 is largely implicated in promoting angiogenesis and tumor metastasis.

Histidine kinases (HK) are largely implicated in environment sensing and stress responses in fungi [ 41].