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Furthermore, the immunogenicity of the recombinant NVLPs has been investigated in animals.
Unfortunately, pharmacological validation is limited and no studies have yet been published where the underlying neural and neurochemical mediators of these biases have been investigated in animals.
Because these electrophilic species are short lived in vivo, they have been investigated in animals and humans by measuring their adducts with hemoglobin, serum albumin, and bone-marrow proteins (Bechtold et al. 1992; McDonald et al. 1993; Rappaport et al. 2002a; Waidyanatha et al. 1998; Yeowell-O'Connell et al. 1996, 2001).
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Only 30 of those chemicals had been investigated in animal cancer tests, 21 of which tested positive for mutagenicity.
Several biomaterial-based strategies have been investigated in animal models.
The antimalarial activity of A.annua tea or extracts has been investigated in animal experiments [52, 53].
The role of β-adrenergic stimulation on viral myocarditis has been investigated in animal models.
The potential role of nVNS in migraine-associated pain and CSD has been investigated in animal studies [21, 42, 43].
Although Tregs have been investigated in animal models and human subjects with autoimmune conditions and type 1 diabetes, the role of Tregs in diet-induced experimental obesity has been only recently recognized [3], [7].
Pain has been investigated in animal models and humans.
Many more neuroprotective strategies have been investigated in animal experiments.
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