Sentence examples for been initially implicated in from inspiring English sources

In particular, CD4+ Th cells producing IL-17 and IL-22, named Th17, have been initially implicated in the pathogenesis of many chronic inflammatory disorders instead of Th1 cells.

Residues 126, 129 and 155 were initially implicated in the binding of AVFluIgG03 since differences at these positions were identified between the 2005 clade 2.3 and1/05 and the clade 0 and clade 1 viruses which failed to react with the AVFluIgG03 by MN and HI tests (Table 2 4).

The phagocyte NADPH oxidase NOX2 was initially implicated in innate immunity and inflammation.

They were initially implicated in feeding behavior and sleep\wake cycles (de Lecea et al., 1998; Sakurai et al., 1998).

The upstream region was initially implicated in rheumatoid arthritis (RA) susceptibility in the Wellcome Trust Case Control Consortium study [ 2], and was subsequently replicated in large European and American populations [ 3, 4].

Defective autophagy was initially implicated in neurodegenerative disease because increased levels of autophagic vacuoles were observed in AD, HD and PD patient brain tissues as well as in animal models of each disease (reviewed in [71]).

Chlamydial protease, or proteasome-like activity factor (CPAF), which is a potent and promiscuous cysteine protease capable of cleaving many host proteins, was initially implicated in this degradation [ 27].

The RAD50 and XRS2 genes were initially implicated in controlling end resection because the mutants show a marked delay in the initiation of resection at endonuclease-induced DSBs; however, recombination products are still produced, but with delayed kinetics and lower yield than wild-type cells (Ivanov et al. 1994).

CBP/p300 was initially implicated the transcriptional activation imposed by phosphorylated CREB [41].

12 PIs were initially implicated as the primary cause of the observed changes.

Initially implicated in feeding behavior, they were also found to regulate cortical arousal and the sleep-waking cycle.