In addition to an abnormal chest x ray, contrast enhanced spiral CT of the lungs is indicated in older patients to exclude thrombus in the central pulmonary arteries and chronic thrombo-embolic disease.
Flecainide drug monitoring (plasma levels and ECG changes) are indicated in older patients who present an age-dependent decrease in renal function and multiple comorbidities frequently associated with structural heart diseases (CAD, hypertension, HF, chronic kidney diseases) which result in polypharmacy and increased risk of drug drug interactions and proarrhythmic effects.
PKC-dependent signalling has been indicated in plasma membranes of young intact 90-day-old rats.
Nevertheless, there may be rare circumstances where meniscal repair may be indicated in the older adult, provided there is good quality tissue, an acute tear and appropriate vascularity.
Older adults are at increased risk of developing vitamin D insufficiency (<30 ng/mL), and a recent systematic review of vitamin D supplementation reports that supplementation may <span class="lh lhl">be indicated in those older people with low vitamin D levels to combat sarcopenia, functional decline, and falls risk.
Cardiovascular prevention with statins, especially secondary benefit, emerges fairly quickly (within 1 2 years), suggesting that statins may be indicated in nearly all older adults with diabetes except those with very limited life expectancy.
Treatment of hypertension is indicated in virtually all older adults, and lipid and aspirin therapy may benefit those with life expectancy at least equal to the time frame of primary or secondary prevention trials.
Treatment of hypertension is indicated in virtually all older adults, and lipid and aspirin therapy may benefit those with life expectancy at least equal to the timeframe of primary or secondary prevention trials.
For CPGs extracted from the two existing reviews, we combined step 1 and 2. When no specific age cut-off for older adults was indicated in the CPG, we looked for words that signified older age (e.g., senior, frail, elderly).
In the lungs, heart wall, kidneys, and liver, data points that are exclusively derived from patients <1 year <span class="lh lhl">old (newborns) are indicated in red.
