However, relatively few patients have been included in randomized trials, indicating a need for more studies to secure valid conclusions.
Ultimately, splenic flexure location has never been included in randomized controlled trials designed to assess the efficacy of laparoscopic surgery as a curative treatment for colon cancer.
This could ultimately be the reason why splenic flexure cancers have never been included in randomized controlled trials, since their resection implies some technical difficulties, including laparoscopic identification of middle and left colic vessels and subsequent lymph node dissection.
If feasible placebo should be included in randomized, controlled trials (RCTs) comparing two presumable active drugs.
During 2000-2004, 125 patients with non-acute NSP were included in a randomized, controlled trial to compare a cognitive-behavioural programme with traditional primary care [ 9].
68 consecutive posterior cruciate retaining TKAs (Interax; Howmedica, Rutherford, NJ) performed in 48 patients because of osteoarthritis or rheumatoid arthritis, were included in a randomized, controlled trial in an academic hospital between 1993 and 1998.
All were included in the Randomized Patients Population (efficacy analysis) and the Treated Patients Population (safety analysis), and analyses were by randomized treatment group.
One hundred patients with medium and large varices who had never bled and were without ascites were included in a prospective, randomized, multicenter, double-blind, placebo-controlled trial.
CABG was performed in 287 patients, who were included in a prospective, randomized study.
When eligible they are included in the study, randomized and receive study drug or placebo.
One-hundred-and-sixty RA patients were included in the multicenter, randomized, double-blinded, parallel-group, placebo-controlled CIMESTRA trial [ 23, 24].
