Although the NTD RSK1 was shown to form a complex with an ATP analogue and two inhibitors, staurosporine and purvalanol A, the authors indicated that the structural conformation of RSK1 was inactive because the ATP analogue was bound in an orientation not favorable for phospho-transfer and the protein was also catalytically inactive in solution.
Although present, HSL may also be inactive because the positive regulator of the 5'AMPK protein PRKAB2 is under-expressed.
Cav (and other) channels in transit may be inactive because the intervening environment is hostile (e.g., inactivation by sustained depolarization, lipids, pH, etc).
Only a fraction is able to retrotranspose and the highest proportion is inactive because the coding sequence of most retrotransposons is truncated or heavily rearranged.
However, the Neisserial Sigma-54 protein is inactive because the two helices that interact with the -13 promoter region [ 61] are missing in this protein [ 62].
In the proposed basal state, SHP-2 is inactive because the 'backside loop' of the N-SH2 domain is associated with catalytic cleft and maintained in a closed state.
Furthermore, node B is inactive because the absence of the DOX input, which prevents the rtTA protein from activating the TRE of nodes C and E. Therefore, in the "10" state, the downstream effect of node A being OFF and node B being OFF results in tagCFP being produced as the sole output.
The account had been inactive because of the National Hockey League lockout.
The high molecular weight P-TEFb is inactive because of the HEXIM1 that introduces its inhibitory PYNT sequence into the active site of CDK9 [ 34].
This cytoplasmic location suggests that ER-β is inactive because of the absence of a ligand, because these receptors can escape rapidly from the nucleus and shuttle repeatedly between nucleus and cytoplasm [ 27].
