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We compared the detection frequencies of the QTL in the following 3 scenarios: (1) in the total population fingerprinted with the original 90 k SNP marker data set, (2) in the assumed available genotypic profiles of the total population of 371 lines irrespective of imputation, and (3) in the total panel for which non-available 90 k SNP array data had been imputed by three imputation approaches.
Missing values have been imputed by hot deck imputation based on Gower distance in morbidity and other variables.
The strains we examined from the Saccharomyces Genome Resequencing Project include nucleotides that have been imputed by taking into account phylogenetic relationships between strains to correct likely sequencing errors and fill in missing data (Liti et al. 2008).
Missing values on categorical independent variables have been coded as a separate dummy variable; missing values on continuous independent variables have been imputed by conditional country means. 2 With the exception of household income (18%%), values were missing in less than 1%% of the cases.
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The remaining SNPs were referred to as untyped SNPs and their genotypes were subject to be imputed by imputation methods.
Missing values will be imputed by multiple imputations assuming data are missing at random.
Missing values (ranging between 5 and 30%) were imputed by multiple imputation.
For the secondary outcome measures, missing values will be imputed by multiple imputation techniques.
Missing variables were imputed by multiple imputation (n = 5) using the mi command in Stata.
These scores were imputed by multiple imputation and included in analysis.
Secondly, missing values were imputed by multiple imputations by chained equations [ 11] for construction of a combined set.
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CEO of Professional Science Editing for Scientists @ prosciediting.com