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The AxxA mutation interferes with the interaction of Nef with SH3 domain containing host cell proteins that have been implied in several Nef activities including host cell signal transduction and sorting processes [30], [31].
Its cytochrome P450 monooxygenases have recently been implied in several of these biotransformations.
The PPP1C/PPP1R2 complex has been implied in several processes such as cardiac function [ 22- 24], mitosis and meiosis [ 25- 30], tubulin acetylation and neuronal cell survival [ 31].
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These authors referred to the IPV screening trial findings as "inconclusive", which was not the interpretation provided in the conclusion of the trial (nor in the accompanying editorial), but rather their own, a framing that occurred explicitly in at least one additional source [ 53], and was implied in several others.
Several lines of evidences indicate that aberrant expression of p66shc could be implied in various stages of carcinogenesis [ 13- 19].
Intriguingly, CCL22 has been implied in the HIV pathogenesis in several ways.
Deregulation of COX-2 has been implied in the pathogenesis of several cancers, in particular colorectal cancer, where it impacts on oncogenic signaling, invasion and metastasis, survival and angiogenesis.
The significance of homoplasmic variations in mtDNA remains uncertain, though several homoplasmic mutations have been implied in disease processes.
Further analysis of differentially expressed genes identified several factors that have previously been implied in skin homeostasis.
Several reviewers were unhappy with the second episode's revelation that Blaine was a junior, not a senior like Kurt, as had been implied in the previous season.
Several signaling mechanisms beyond cell surface receptors, which are activated by adrenergic signaling and other neuroendocrine compensatory systems, have been implied in the pathogenesis of chronic heart failure.
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