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Secreted modular calcium binding protein-1 (Smoc-1) belongs to the BM-40 family which has been implicated with tissue remodeling, angiogenesis and bone mineralization.
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Augmented oxidoreductase gene expression suggests that oxidative stress may contribute to respiratory muscle dysfunction, as has been implicated with diabetes in other tissues [61].
Thrombospondin 2 (TSP2), a matricellular protein with a primary role in modulating cell-matrix interactions, has been implicated in tissue repair and foreign body responses.
Surprisingly, signaling via the IL-4Rα in macrophages, which have been implicated in tissue repair, is dispensable for hepatocyte proliferation and liver regrowth after injury.
Hippo signaling serves to limit organ size and suppress malignancies, and has been implicated in tissue regeneration following injury.
Tissue resident macrophages have been implicated in tissue injury and repair (Yamasaki et al., 2014; Zigmond et al., 2014; Stamatiades et al., 2016).
Phagocyte generated free radicals have been implicated in mediating tissue damage associated with various inflammatory vasculopathies.
Complement has long been implicated in mediating tissue injury in ischaemic organs, with or without reperfusion.
Genes with bimodal expression profiles in both organisms may indicate conservation of alternative promoters, which have been implicated in tissue-specific expression common among the bimodal genes.
We excluded patients with autoimmune disease because peroxynitrites have been implicated in the pathogenesis of tissue damage in autoimmune disease.
IL-17 has also been implicated in PsA, with an increased number of Th17 cells in the peripheral blood, synovial fluid, and synovial tissue of PsA patients (5– 7).
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