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Several of the shared overexpressed genes are members of the Wnt-signaling pathway that has been implicated with female reproductive development in mammals (Bernard and Harley 2007) and also in some fish species (Wu and Chang 2009).
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Sex differences in the magnitude of genetic contributions have also been implicated, with greater effects among males than females, especially during adolescence [ 35– 35].
Halper contacted Page and Papadopoulos only after they had already been implicated with ties to Russia.
Sphingomyelins (SM) and phosphocholines (ceramides) have earlier been implicated with the pathophysiology of OAG [99].
Dmrt2 was highly overexpressed in all female/ovary samples in our experiments, and has been implicated with sex determination before (Matsushita et al. 2007; Sheng et al. 2014).
In C. elegans, NASP-1 has been implicated in female development through its interactions with histone deacetylase and TRA-4 proteins [ 18].
Adipokines, secreted from adipocytes, have been implicated in female fertility and obesity [ 69].
Oxidative stress has been implicated in different female diseases including polycystic ovarian syndrome (PCOS).
It has been implicated that a female fetus alters maternal asthma during pregnancy by upregulating maternal inflammatory pathways (28).
The Pri2 CTD has been implicated in association with several proteins involved in replication initiation.
It was noted that many of the genes associated with female pregnancy have also been implicated in pregnancy-related disorders.
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