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Some maternal factors have been implicated with altered sex ratio such as maternal age, parity, and race [ 36].
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DA has also been implicated with a role in the expression of feather pecking behavior [ 30] and, as mentioned above, TH is altered in laying hens from a low mortality selection line [ 20].
Accordingly, diverse Gene Ontology (GO) terms were implicated with both patterns of altered gene expression; however, those showing non-additive expression manifested a significant enrichment for a specific group of proteins associated with vesicle function.
Although altered UPS functioning is implicated with diminished cardiac function, it remains unclear whether greater or lesser UPS activation is detrimental with ischemia reperfusion under such conditions.
The PI3K/AKT signaling pathway has also been implicated in altering breast cancer response to multiple therapies [1], [10], [11], [14].
CIA1 is a yeast gene that has not been implicated in altering yeast prion propagation.
However, aging has been implicated to alter leptin and insulin sensitivity in rodents [ 2].
Besides TNF α, several other cytokines have been implicated in altering intestinal permeability.
Importantly, JARID1A has been implicated in facilitating an altered chromatin state that promotes drug-tolerant subpopulations of cancer cells [ 171].
Therefore, HDACs may be implicated in altered gene expression profiles in the medial hypothalamus under different metabolic states.
In light of the current data set, we propose that a non-canonical mechanism (perhaps associated with metabolic dysfunction) is implicated in altering the calcium regulation in LCR myocytes thus giving rise to the contractile dysfunction observed in these hearts.
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