Sentence examples for been implicated to mediate from inspiring English sources

These functions of CD38 as ectoenzyme and receptor have been implicated to mediate the humoral and innate immune response of lymphoid and myeloid lineage cells [5], [9].

Inhibitory KIR2D receptors are divided into two families based on their specificities for different HLA-C allotypes and residue 80 of HLA-C has been implicated to mediate this specificity [20].

The observed antioxidant activity is significant because free radicals have been implicated to mediate in stress, NSAID and H. Pylori induced gastric ulcers [ 5, 29].

We also monitored two effectors that have been implicated to mediate Ret-regulated cell proliferation and differentiation, i.e. Akt and Erk (Airaksinen and Saarma, 2002; Asai et al., 2006; Hayashi et al., 2000; Mograbi et al., 2001).

Previously, an autocrine TNF α loop has been implicated to mediate apoptosis upon single agent treatment with cytotoxic concentrations of Smac mimetics that stimulate the production of TNF α, thereby initiating TNFR1-mediated cell death.

Although an autocrine/paracrine TNF α loop has been implicated to mediate Smac mimetic-induced cell death, little is yet known about additional factors that determine sensitivity of cancer cells to Smac mimetic-triggered apoptosis.

PKG protein kinase G (=cGMP-dependent protein kinase) and PKA are implicated to mediate the downstream effects of NPs and β-adrenergic receptor, respectively, and both signalling pathways converge on p38 MAPK (mitogen-activated protein kinase).

In mice, these behaviors have been implicated to be mediated by peptide pheromones that are sensed by a class of G protein-coupled receptors, vomeronasal receptor type 2 (V2Rs), expressed in the pheromone detecting vomeronasal organ.

Furthermore, membrane localization of ERα and ERβ has been demonstrated in glia cells in different brain regions [43], [45], [47], [48], and glia cells have also been implicated to participate in mediating estrogen neuroprotection via the release of growth factors and neuroactive steroids [49], [50], [51].

Various IRES trans acting factors or ITAFs have been implicated to have role in mediating internal initiation of translation.

Genome-wide aberrations of the classic epigenetic modification 5-methylcytosine (5mC), considered the hallmark of gene silencing, has been implicated to play a pivotal role in mediating carcinogenic transformation of healthy cells.