Whilst no studies have demonstrated a role of MTA2 or the effects of histone acetylation in human implantation, the Rho signalling pathway has been implicated to have a role in inducing human trophoblast invasion and migration (Saso et al., 2012) The downregulation of MTA2 by miR-661, may therefore inhibit activation of MTA2 target genes, such as Rho, which are required for embryo implantation.
Similar to most other polyphenols, resveratrol is suggested to possess intrinsic anti-oxidant capacity, but it is also implicated to induce the expression of a number of anti-oxidant enzymes, with probably both mechanisms contributing to an overall reduction in oxidative stress [ 32].
As only high ATP concentrations induced SC death, P2X7R is implicated to be the receptor responsible for SC death.
Next we examined whether HSF1 over-expression increases markers of epithelial-to-mesenchymal transition (EMT), which has been implicated in inducing the CSC phenotype [ 10].
Myb transcription factors have been implicated in inducing the stress response in plants in response to various abiotic stresses including phosphate stress [ 37] and asian soybean rust [ 38].
ESAT-6 is a secreted protein of Mtb, which is absent in BCG but has been implicated in inducing protective immunity against Mtb.
In addition, coxsackievirus B, cytomegalovirus, adenovirus, and mumps have been implicated in inducing certain cases of the disease.
Likewise, FGF7 and FGF10 have been implicated in androgen induced ductal growth and branching morphogenesis during embryogenesis [16], [17].
Recently, oxidized products from plant carotenoids have been implicated as signals induced by environmental stressors [ 8].
