Sentence examples for been implicated to facilitate from inspiring English sources

Interactions of L-selectin on leukocytes [ 30], E- and P-selectin on the vascular endothelium [ 31- 33], and P-selectin on platelets [ 34] with their ligands have been implicated to facilitate the metastasis of carcinoma cells.

Negatively charged macromolecules or polyanions, including nucleic acids [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], phospholipids [21], [22], [23], [24] and glycosaminoglycans (GAGs) have been implicated as facilitating cofactors in the conversion of PrPC to PrPSc and thereby in the transmission and pathogenesis of prion disease.

Proteolytic enzymes have been implicated in facilitating tumor cell invasion and the current study was designed to characterize the expression of the cysteine proteinase cathepsin S (CatS) in astrocytomas and examine its potential role in invasion.

As plasminogen recruitment and the plasminogen-activated fibrinolytic system have been implicated in facilitating microbial pathogenesis, we next examined the influence of capsule formation on the cell wall surface accessibility and plasminogen binding capacity of the serotype D strains JEC21, FCH78 (cap59::nat), and FCH79 (CAP59 cap59::nat) and the serotype A isolates C23 and A1 38-2.

Indeed, neutrophils have been implicated in facilitating tumor cell extravasation.

Importantly, JARID1A has been implicated in facilitating an altered chromatin state that promotes drug-tolerant subpopulations of cancer cells [ 171].

VHL has been implicated in facilitating TNF-α-induced apoptosis by suppressing the expression of NF-κB-dependent anti-apoptotic genes (Qi & Ohh, 2003).

Kallikrein proteins have also been implicated in facilitating angiogenesis via degradation of the cellular matrix [ 109] and our data showed co-regulation of Pgf and Kallikrein genes.

Aberrant activation of K-Ras has been implicated in facilitating all aspects of a malignant phenotype, including proliferation, invasion and metastases by Ras effectors such as PIK3, Raf/MEK/ERK cascade and Rho GTPases.

LRR-flanking cysteines have also been implicated in facilitating interactions with other proteins as in the case of mammalian TLR4 and its MD-2 (myeloid differentiation protein) partner required for the recognition of lipopolysaccharide [ 29].

It has been implicated as an oncogene to facilitate cell growth and survival.