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UPS function has been implicated to exert a central role in the pathogenesis of various human diseases.
17β-estradiol (E2) has been implicated to exert neuroprotective effects in the brain following cerebral ischemia.
Semen analysis is sometimes subject to the evaluators' individual judgement and has been implicated to exert limited predictive value in determining sperm function and fertility potential, as demonstrated by the noted discrepancies in cases when men with normal semen parameters have repeated fertilization failure, while men with very abnormal semen characteristics have fathered children.
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Astrocytes have been implicated as potentially exerting both neurotoxic and neuroprotective activities in Parkinson's disease.
Besides regulating G protein signaling by accelerating the GTPase activity of Gα subunits, RGS proteins are implicated in exerting other functions; they are also known to be involved in several diseases.
Later on, Ojiako and co-workers [ 15] reported another study in which extracts from VA leaves were implicated in exerting toxicity action on the study subjects, mice.
CSE and endogenous H2S have also been implicated in atherogenesis: Overexpression of CSE exerted anti-atherosclerotic effects [45], whereas CSE knockout promoted disease progression in a murine model of diet-induced atherosclerosis [46].
NGF has been shown to exert neuroprotective effects and even has been implicated in the treatment of chronic neurodegenerative diseases such as glaucoma and Alzheimer's disease [ 2, 3].
Notably, many snoRNAs (e.g., SNORD115 [ 130 ]) exert similar splicing control on a wide range of genes, some of which have been implicated with prostate cancer progression to a metastatic stage [ 129, 131, 132 ].
Although a variety of soluble mediator molecules have been implicated [14], the molecular mechanisms by which MSC exert their immunomodulatory effects are presently not well understood.
The neuropeptide oxytocin (OT) and the steroid cortisol (CT) have each been implicated in complex social behavior, including parenting, and one mechanism by which OT is thought to exert its pro-social effects is by attenuating hypothalamic pituitary adrenal (HPA) response to stress.
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been identified to exert
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been described to exert
been implicated to play
been shown to exert
been implicated to have
been known to exert
been implicated to mediate
been implicated to regulate
been implicated to participate
been implicated to cause
been suggested to exert
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