Both somatic and germline mutations have been implicated to cause prostate cancer.
Recently, however, the gene C16orf57 has been implicated to cause PN.
High dose of L-ornithine has also been implicated to cause acute pancreatitis [ 22].
ADPKD is inherited in an autosomal dominant fashion, and so far two genes, PKD1 and PKD2, have been implicated to cause the disease [ 2].
Furthermore, TAZ-CAMTA1 (calmodulin-binding transcription activator) fusion gene arising due to chromosomal translocation has been implicated to cause epitheloid hemangioendothelioma, a vascular sarcoma., Apart from this gene fusion, all other YAP and TAZ mediated tumorigenesis is due to overexpression.
The organisms like Escherichia, Enterobacter, Klebsiella, Proteus, Shigella and Staphylococcus species are implicated to cause severe infections in human, as they are found in multiple environmental habitats [ 18, 19].
To further challenge the power of the observed differences, we performed hierarchical classification analysis on all of those AS regions that were implicated to cause NMD in the mixed patients' cohort, and found correct classification of all samples except for 2 misclassifications.
The Makassar Strait is implicated to have caused a disjunction and a physical barrier to biotic exchanges or gene flow between the common ancestors of all extant mycalesines on the mainland Asian and Sulawesi at the time.
Its deficiency has been implicated to be the underlying cause for histidinemia in human and mouse [ 31- 35], which in human can lead to abnormal development in children, including mental retardation (http://en.wikipedia.org/wiki/Histidinemia) [ 31, 32, 34, 35].
Interestingly, mutations in ABCA4 were also implicated to cause hereditary bull's eye maculopathy (BEM) [ 12, 13], a phenotype reminiscent of toxic maculopathy.
Although generally the non-synonymous and stop-loss or stop-gain SNPs are implicated to be disease causing, the synonymous SNPs can be useful by being in strong LD with functional mutations.
