The PI3K/AKT signaling pathway has also been implicated in altering breast cancer response to multiple therapies [1], [10], [11], [14].
Whereas the low levels of hypophosphorylated RB1 reported for other Lmna/LMNA deficient cells have been implicated in altering the G1/S transition, our findings with LmnaDhe/+ fibroblasts suggest that the influence of RB1 extends to mitosis as well [11], [19], [26], [28], [39] [42].
More recently, Myc deregulation has been implicated in altering cellular metabolism, particularly by inducing both the Warburg effect and a reliance on exogenous glutamine [18], [25], [49].
The electrostatic properties of helix macrodipoles have previously been implicated in altering the reactivity (significantly reducing the pKa) of cysteine residues positioned at the N-termini of α-helices [30].
CIA1 is a yeast gene that has not been implicated in altering yeast prion propagation.
Besides TNF α, several other cytokines have been implicated in altering intestinal permeability.
As chemo- and radiotherapy have previously been implicated in altering methylation patterns, no subjects who had received either type of treatment were included in the study.
These parasitic entities have been implicated in altering structural, functional and epigenetic variability of their host genome [ 13], consequently enhancing the evolvability of species and lineages.
128 Finally, increases in this essential bacterial micronutrient have been implicated in altering reef community structure and function in extremely oligotrophic environments, such as isolated coral atolls.
