Likewise, RNA polymerase has also been implicated to afford both incentive force and directionality for segregation through interacting with origin-proximal regions [ 10, 11].
NLRP12 has also been implicated to play a role in inflammation and tumorigenesis in the colon.
Numerous mutations have been described in the RB1 gene but several other genes have also been implicated to play a role in retinoblastoma.
Cholesterol is thought to be important for the lateral organization of eukaryotic cell membranes and has also been implicated to take part in the sorting of cellular transmembrane proteins.
Similarly, sulfolipids (SL) have also been implicated to play a role in virulence and at day 90, MmpL8 and PapA1 were found to be present [32], [33].
Interestingly, IRF2 has also been implicated to stimulate certain genes under various conditions, such as vascular cell adhesion molecule (VCAM), histone H4 genes etc [7], [8].
Several other molecules have also been implicated to play roles as adaptor proteins downstream of MAVS and TRAF3 including NEMO, TANK, SINTBAD, and NAP1 [23], [24], [24].
However, since GABA has also been implicated to have an excitatory role on GnRH neurons, an alternative interpretation is that there may be increased excitatory drive to GnRH neurons in the middle-aged animals.
Reduced monomeric apo-SOD1 has also been implicated to initiate aggregation of dimeric holo-SOD1 at neutral pH and 37°C [16], and disulfide-reduced SOD1 species are enriched in the spinal cords of ALS mice [17].
A number of correlated genes have also been implicated to function in regulating the transcription of defense related genes including two WRKY family transcription factors (TFs) (WRKY28, r = 0.820, At4g18170 and WRKY15, r = 0.790, At2g23320) [60].
