Cis trans isomerization is notoriously slow and is catalyzed by a family of cis trans peptidyl prolyl isomerases (PPIases) that have been implicated in many diseases.
The sigma-1 receptor is a unique non-opioid, non-PCP binding site that has been implicated in many different pathophysiological conditions including psychosis, drug addiction, retinal degeneration and cancer.
BRCA1 is a multifunctional protein that has been implicated in many cellular processes, including genomic stability, the cell-cycle checkpoint, DNA-damage repair, apoptosis, and gene transcription [1].
Th17 cells have attracted wide interest as they have been implicated in many inflammatory diseases that were previously only linked to Th1 responses, including rheumatoid arthritis, psoriasis, multiple sclerosis and Crohn's disease [43], [44], [45], [46], [47].
DNA cytosine methylation is an epigenetic modification that has been implicated in many biological processes.
TNF-α is a potent cytokine that has been implicated in many immune-mediated disorders.
TNF-alpha encodes a multifunctional cytokine that has been implicated in many diseases including cancer [ 44].
The Src family consists of 11 members that have been implicated in many cellular functions, including cell proliferation, differentiation, apoptosis and migration [ 25, 26].
K. pneumoniae is a facultative anaerobic, Gram negative bacteria of the Enterobacteriaceae family, and a reported opportunistic pathogen that has been implicated in many community- and hospital-acquired infections [ 1].
DOI: http://dx.doi.org/10.7554/eLife.01085.002 Septins are ubiquitous guanine nucleotide-binding proteins that have been implicated in many cellular processes such as cytokinesis, spindle positioning, morphogenesis, and exocytosis, and their mutation or overexpression is associated with neoplasia, neurodegenerative diseases and male infertility (Hall and Russell, 2004).
