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Some of the pathways that have been implicated so far include mitochondrial dysfunction, oxidative stress, kinase pathways, calcium dysregulation, inflammation, protein handling, and prion-like processes.
However, adherens junctions have not been implicated so far.
The two remaining neurons, AVKL and SMBVL, have not been implicated so far in any known functional circuit.
No other Hsa21 genes have been implicated so far.
However, their functional characterization would be required to ascertain if they play some unique role(s) in plant processes, in which NAC proteins have not been implicated, so far.
Similar(55)
Certainly, no functional significance has been attributed to the TCF7L2 variants implicated so far, all of which are intronic.
If the officials he has implicated so far are allowed to walk, he said, he will act decisively.
It is genetically heterogeneous (over 60 genes implicated so far) and associated with significant variability in age of onset, disease progression and retinal appearance (RetNet; http://www.sph.uth.tmc.edu/retnet/, accessed 31 December 2014).
Interestingly, the L. donovani A2 genes (pseudogenes in L. major), the only genes implicated so far in disease tropism [ 62], are specifically expressed in amastigotes [ 11].
These differences may reflect different disease triggers between children and adults, but whilst various viral and other environmental triggers have been implicated, results are so far conflicting.
Temer also appointed several officials who are under investigation for corruption, including some who have been implicated in the far-ranging so-called Car Wash scandal, involving the state-owned oil company Petrobras, in which dozens of government officials and legislators are suspected of taking bribes and kickbacks.
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