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Mycobacterium tuberculosis possesses unique cell-surface lipids that have been implicated in virulence.
Protease inhibitors have been implicated in virulence of the oomycete plant pathogen Phytophthora infestans.
PB1 gene encodes a polypeptide of almost 80 amino acids, with specific polymorphism and has been implicated in virulence of virus with specific polymorphism (Chen et al., 2001).
PPK has also been implicated in virulence and in-vivo growth in several bacteria.
In addition, ARs 11, 30 and 34, which encode the pilus, pneumococcal collagen-like protein (PclA) and PsrP, respectively, have been implicated in virulence [10], [16], [19], [69].
The T6SS has been implicated in virulence of V. cholerae [2], Pseudomonas aeruginosa [3], Edwardsiella tarda [4], [5], Burkholderia species [6], [7], [8], and Aeromonas hydrophila [9].
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Two further polymorphic ROP2 family members have been implicated in virulence-related behaviour.
Influenza viruses have several proteins that are implicated in virulence: the surface proteins hemagglutinin (HA) and neuraminidase (NA), the polymerase complex (including the PB1, PB2 and PA proteins), and the non-structural proteins [2].
It has been proposed that lipoproteins are implicated in virulence in E. faecalis [56].
The entire region is transcriptionally regulated by MglA, which is implicated in virulence [16].
These observations are particularly interesting as both efaCBA and sodA have been shown to be implicated in virulence [38], [82].
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