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Arfaptins have been implicated in vesicle formation at the GA and in the cell periphery (Mim et al., 2012; Peter et al., 2004).
Otoferlin plays a crucial role in vesicle release at the synapse between IHCs and auditory nerve fibers by interacting with syntaxin1 and SNAP25 [ 15], and it has recently been implicated in vesicle replenishment at the presynaptic membrane [ 16].
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In addition to acting as a diffusion barrier, animal septins are implicated in vesicle trafficking, apoptosis and cell movement [ 6].
ARF genes are implicated in vesicle trafficking – a critical process for cell polarity during development of yeast, animals and plants.
Similarly, 3 out of 10 genes within 10 kb of a DpnII fragment associated with CNC6 are implicated in vesicle-mediated transport (ITNS1, SYNJ1 and DOPEY2; P = 1.28×10−3).
The integral synaptic vesicle protein and putative calcium sensor, synaptotagmin 1 (STG), has also been implicated in synaptic vesicle (SV) recovery.
In addition, AP3 has been implicated in synaptic vesicle recycling in neurons (Voglmaier et al, 2006), which suggests that this is indeed a potential pathway for vesicle formation from endosomes.
In addition, various Rho-GTPases have been implicated in intracellular vesicle trafficking.
Rab2A has previously been implicated in intercellular vesicle trafficking regulation (Stenmark, 2009; Tisdale and Balch, 1996).
It is an abundant protein that associates with biological membranes as well as the actin cytoskeleton, and has been implicated in intracellular vesicle fusion, the organization of membrane domains, lipid rafts and membrane-cytoskeleton contacts.
Although PLD1 has likewise been implicated in retrograde vesicle movement in the Golgi and receptor endocytosis [ 16, 19, 20], both PLD1 and PLD2 have also reported to provide a survival signal that overcomes cell cycle arrest and apoptotic cell death [ 21].
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