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Rac1 has been implicated in transformation and metastasis [ 25, 42, 43].
Alterations in PKC isoenzyme expression have been implicated in transformation events in a number of cell types [ 13].
Overexpression and increased activity of PKC β have been implicated in transformation and tumourigenesis in lung cancer (Barr et al, 1997; Lahn et al, 2006).
Malignant activation of the VEGF signalling pathway has been widely implicated in the tumour growth and lymphangiogenesis of NHLs and the expression of VEGF has been considered as a poor prognostic factor in these hematological malignancies and has been implicated in transformation of FL to DLBCL [ 42– 42].
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Glutamate receptors are implicated in transformation to malignancy; it's hypothesized that glutamate receptors overexpression may be a common feature of tumor pathogenesis.
PAK1 has been reported to have a number of functions (e.g. cell survival, motility, proliferation) and is implicated in transformation and tumour progression (Huynh et al., 2010).
This CYP450 was pulled out of the genome by local BLASTp using a collection of vector beetle CYP450s (Dendroctonus spp.; Cano-Ramírez et al. 2013) that were implicated in transformations of α-pinene, possibly to verbenol.
The Warburg effect has been implicated in cell transformation, immortalization, and proliferation during tumorigenesis [10].
Aberrant DNA damage responses and increased accumulation of DNA damage has been implicated in malignant transformation in the hematopoietic system.
Constitutive activation of the CD40 pathway has been implicated in cell transformation and neoplastic growth [26].
Checkpoint loss results in genomic instability and has been implicated in the transformation of normal cells into cancer cells [42].
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