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Hippo signaling serves to limit organ size and suppress malignancies, and has been implicated in tissue regeneration following injury.
In this respect, complement proteins have been implicated in tissue and organ regeneration in both urodeles and mammals.
Tissue resident macrophages have been implicated in tissue injury and repair (Yamasaki et al., 2014; Zigmond et al., 2014; Stamatiades et al., 2016).
Thrombospondin 2 (TSP2), a matricellular protein with a primary role in modulating cell-matrix interactions, has been implicated in tissue repair and foreign body responses.
ILC3s have also been implicated in tissue repair following inflammation or damage in multiple tissues, including intestines, thymi, and lungs (Dudakov et al., 2012; Sawa et al., 2011; Taube et al., 2011).
In addition, SASP has also been implicated in tissue regeneration after damage.
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In mammals, DNA methylation has been implicated in tissue-specific gene regulation, parental imprinting and silencing of transposable elements [ 3, 5, 7].
Genes with bimodal expression profiles in both organisms may indicate conservation of alternative promoters, which have been implicated in tissue-specific expression common among the bimodal genes.
It has been reported previously that NETs are implicated in tissue damage during E. coli sepsis [22].
Recently, accumulated evidences support that connective tissue growth factor (CTGF) is implicated in tissue repair of many tissues.
Multipotent mesenchymal stem cells (MSCs) are widespread in adult organisms and are implicated in tissue maintenance and repair, regulation of hematopoiesis, and immunologic responses.
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