Sentence examples for been implicated in targeting from inspiring English sources

Noncoding RNAs have been implicated in targeting the repressive polycomb complex PRC2 to specific genomic sites.

In addition to Ubr1, other ubiquitin ligases have been implicated in targeting yeast cytosolic proteins.

Furthermore, miR-139 has been implicated in targeting CXCR4 in cancer.

Moreover, miR-512 has been implicated in targeting the pro-survival gene MCL-1 that is expressed at very low levels in this subset [ 66].

Multiple proteins have been implicated in targeting p300 to UV damage, including Ing1B [ 67], DDB1 [ 68], PCNA [ 69], CSB [ 18] and p53 [ 70].

miR162 has been implicated in targeting DCL1 [ 13], miR168 in AGO1 mRNA [ 14– 16] and miR403 in targeting AGO2 and AGO3 mRNAs in Arabidopsis and other related plants [ 17– 17].

ERM (Ezrin/Radixin/Moesin) domain containing proteins couple cell surface receptors to the actin cytoskeleton (Tepass, 2009) and are implicated in targeting synaptic glutamate receptors and extra-synaptic GABAA receptors in neurons (Biederer and Sudhof, 2001; Loebrich et al., 2006).

Ap1b1 is a subunit of the adaptor complex AP-1, which has been implicated in the targeting of basolateral membrane proteins.

In addition, a number of other Rabs are potential candidates for affecting or regulating CNC migration: Rab11 is associated with E-cadherin recycling in mammals and Fly52, while Rab5 and Rab7 have been implicated in lysosomal targeting of E-cadherin53.

A number of cellular proteins have been implicated in Gag targeting to the plasma membrane and in subsequent assembly16; however, the mechanism of action of these host factors remains to be elucidated (Box 1).

Monoubiquitinylation has been implicated in the targeting of membrane proteins for endocytosis and lysosomal degradation [50] and in the regulation of protein complex assembly [51].