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The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation.
The PSO has been implicated in systemic human rights abuses.
The golgins are a group of coiled-coil proteins responsible for tethering specific molecules for transport through the golgi complex [41], and have been implicated in systemic autoimmune diseases such as lupus erythematosus and Sjögren's syndrome [42].
Polymorphisms within the region of Slamf6 (Ly108) have been implicated in systemic lupus erythematosus (SLE) (Wandstrat et al., 2004).
Splanchnic hypoperfusion, particularly at the intestinal mucosal region, has been implicated in systemic inflammatory response and multiple organ dysfunction.
Moreover, various components of the oral microbiota have been implicated in systemic diseases such as pancreatic disease including pancreatic cancer, atherosclerosis, bacteremia, and endocarditis.
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OXT is implicated in systemic salt balance by centrally regulating salt appetite and natriuresis [15].
Wild-type transthyretin also has the potential to form amyloid fibrils and is implicated in systemic senile amyloidosis.
Indeed, the SSPs allergens are heat stable and resistant to enzymatic digestion and are implicated in systemic and life-threatening reactions [ 16, 17].
Although the molecular mechanisms that leads to clinical manifestations in Coats plus syndrome is not known, these results suggest that additional target genes may be implicated in systemic diseases caused by telomere dysfunction.
A role for DNA methylation has also been implicated in scleroderma (systemic sclerosis, SSc).
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