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Besides BCR signaling, several stromal factors have been implicated in sustaining CLL-BC survival.
These include important signalling proteins like EGFR and IGF1-R that have been implicated in sustaining the neoplastic phenotype in OSCC [ 2].
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Melatonin is implicated in sustaining the esophageal integrity in gastro-esophageal reflux disease.
Considering the relationships between nurses, doctors, and patients (rather than merely thinking about nurses, doctors, or patients as individuals) gives a stronger sense of the mutually connected dimensions of such a decision, and the ways in which both doctors and nurses – and inevitably many other health professionals - were implicated in sustaining these unsatisfactory conditions.
Tertiary lymphoid structures in the lung have been implicated in providing sustained protective immunity to viruses and chronic asthma, and in lung cancers, tumor-induced BALT has been associated with increased survival [ 11, 21, 24].
IRF5 has recently been implicated in the sustained TNF α response in dendritic cells upon lipopolysaccharide (LPS) stimulation.
Vascular DCs have been implicated in initiating and sustaining mural inflammation.
In particular, p38 MAPK has a multifaceted role in CD4 T cells that have been implicated in initiating and driving sustained inflammation in autoimmune diseases, such as rheumatoid arthritis or systemic vasculitis.
Both myosin-1c and myosin VIIa have been implicated in the adaptation of mechanoelectrical transduction upon sustained deflection of the hair bundle (29, 30).
COX2 and PGE2 have been implicated in the progression of breast and other cancers and may act to sustain HER2 signaling [27], [28], [29].
On the other hand, PGE 2 has been implicated in the development of colorectal cancer which results from sustained over-expression of cyclooxygenase 2 (Cox-2) [ 12, 13].
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