Sentence examples for been implicated in survival from inspiring English sources

Mer receptor tyrosine kinase is a promising novel cancer therapeutic target in many human cancers, because abnormal activation of Mer has been implicated in survival signaling and chemoresistance.

In accordance with the established role of TRAF2 and TRAF5 in NFκB signaling, CD27 activation results in enhanced activity of the classical and alternative NFκB pathway, which both has been implicated in survival, activation and differentiation of T cells.

JNKs have been shown to serve as mediators of apoptosis in response to cellular stress to sustain cell proliferation [ 17], and have been implicated in survival in response to extracellular stimuli such as cytokines.

Both PIM and LAM have been implicated in survival in macrophages, by amongst other mechanisms, the inhibition of phagolysosomal fusion [ 81], and the modulation of both cytokine responses and of the phagosomal maturation process [ 25].

To determine the signaling pathways responsible for PTK6 downregulation-mediated Bim induction in UACC893R1 and MDA-MB-453 cells, we examined the status of major signaling pathways activated downstream of Her2 that have been implicated in survival, and Bim regulation [ 26, 28].

CXCR7 is implicated in survival and proliferation of breast and lung cancer cells [ 6].

In contrast to pro-apoptotic cytoplasmic FADD, the phosphorylation at Ser-194 is suggested to be essential for the nuclear localization of FADD, and nuclear FADD is implicated in survival mechanisms.

To date, the macroautophagy survival pathway (autophagy) has not been implicated in the survival of malignant precursor cells within human DCIS lesions.

Particularly, increased expression of NEU3 has been implicated in the survival of various cancer cells and also in the development of insulin resistance.

Interruptions in cardiopulmonary resuscitation (CPR), particularly as guided by automated external defibrillators, have been implicated in poor survival from cardiac arrest.

The P13K-AKT pathway, upregulated on SLActive surfaces (in relation to angiogenesis), has also been implicated in neuronal survival and subsequent neural development [77,78] and could have contributed to upregulation of neurogenic genes at these surfaces.