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Additionally, HCV core protein has been implicated in suppressing differentiation, proliferation and function of T cells, dendritic cells and macrophages [33].
These terminal sialic acid residues have recently been implicated in suppressing inflammation via the induction of inhibitory FcãRIIb expression in mice [ 19, 20].
Intriguingly, in recent studies, GC-C signalling has also been implicated in suppressing intestinal tumourigenesis, suggesting that GC-C agonists might potentially be useful for the prevention or therapy of colorectal cancer.
This CNA included several genes that have been implicated in suppressing epithelial tumorigenesis and/or metastasis, such as DICER1 (Martello et al., 2010) and ELF5 (Chakrabarti et al., 2012).
Myc has previously been implicated in suppressing replicative senescence, which is caused by telomere erosion, by activating transcription of hTERT [ 28]. hTERT encodes a major component of telomerase, which is normally expressed in stem cells and prevents telomere shortening, thereby extending the replicative lifespan of cells.
Conversely, progesterone and its metabolite allopregnanolone have been implicated in suppressing irritability.
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Rotherham chief executive Martin Kimber said there was no evidence in the report that led him to conclude Mrs Thacker was implicated in "suppressing information or failing to react appropriately to emerging issues around child sexual exploitation".
He added: "There is no evidence in the report that leads me to conclude Joyce Thacker was implicated in suppressing information or failing to react appropriately to emerging issues around child sexual exploitation".
21 Posterior thalamus was implicated in suppressing the ventilatory response to hypoxia.
Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme that is implicated in suppressing T-cell immunity in many settings including cancer.
IDO is implicated in suppressing T-cell immunity to parasite antigens and IDO inhibition reduced local inflammation and parasite burdens, which suggest that IDO were of benefit for the pathogen, not the host.
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