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The gene had not previously been implicated in stroke, and its detection may open new insights into the mechanisms of the disease.
Although Ccl9 has not been implicated in stroke, brain levels increase in response to infections including pneumococcol meningitis (Klein et al., 2006) and herpes simplex virus (Aravalli et al., 2005).
Misregulation of Hcy is implicated in various cardiovascular diseases and neuropsychiatric conditions, and the elevated Hcy levels found in hyperhomocysteinemia have been implicated in stroke, pre-eclampsia, and Alzeheimer's disease.
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The dynamics of miRNA regulatory network mediated by RNA editing is implicated in stroke.
Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) are implicated in stroke, Alzheimer's disease, and multiple sclerosis [ 7] and constitute potential treatment options for TBI due to their pleiotropicity [ 8].
Furthermore, 25(OH D deficiency has been implicated in sepsis, stroke, inflammatory bowel disease, autoimmune conditions and asthma [ 33- 39].
The death receptor agonists TRAIL and TWEAK have also been implicated in adult stroke models [41], [42] and we recently found that TRAIL Death Receptor signaling is involved in hypoxic ischemic brain injury [36].
Furthermore, our screen had identified proteins that function in multiple pathways, such as the ubiquitin proteasomal pathway, nuclear export and synaptic formation, all of which have been implicated in ischemic stroke.
Furthermore, the IGF system has been implicated in both experimental stroke recovery/susceptibility in patients.
Although infection has been implicated in increasing susceptibility to stroke, few studies have examined how an infection prior to stroke affects outcome.
Bradykinin (Bk) and interleukin-1β (IL-1β) have both been implicated in edema formation after stroke, although acute Bk application itself results in only a modest permeability increase.
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