Sentence examples for been implicated in splicing from inspiring English sources

Furthermore, DJ-1, one of the genes mutated in genetic PD, has been implicated in splicing, through regulation of the splicing of tyrosine hydroxylase by the protein-associated splicing factor (PSF) [57].

In summary, these results indicate that loss of three of the final four group IIA introns for which matK has been implicated in splicing has resulted in relaxed or even positive selection for some codons within domain X in C. nitida.

Recently, CTCF has been implicated in splicing through its action on local RNA polymerase II pausing [ 11], trinucleotide repeat instability [ 12, 13], DNA replication [ 14, 15], and nucleosome positioning [ 16, 17].

They could also play a role in the cognitive impairment, considering that ELP3 regulates the maturation of projection neurons and that SNORD115-32 has been implicated in splicing defects of the serotonin receptor 2C in Prader-Willi syndrome [see Additional file 10: Table S4].

A subset of these proteins, shuttling SR proteins, have not only been implicated in splicing but have also been shown to stimulate translation of a reporter gene when fused to the same transcript [ 65], analogous to a uORF-mORF associated pair.

Our model shows that AGO1 activity downstream of alternative exons correlates with splicing changes in the direction of skipping in MCF7 compared to MCF10, providing further indication that AGO1 association with chromatin could be implicated in splicing regulation [ 4, 21, 35, 37].

This rare class of donor splice signals has been implicated in alternative splicing [ 9, 11, 12].

As a member of the large hnRNP family, hnRNP I has been implicated in mRNA splicing.

A PTB7-like protein was also identified in pumpkin phloem and its orthologs in Arabidopsis have been implicated in alternative splicing [ 2, 57].

Almost all of the genes in cluster 78 have been implicated in alternative splicing, e.g. recent studies of KHDRBS1, aka Sam68 [ 31].

Consistent with these findings, PB has been implicated in the splicing of mitochondrial introns as the respiratory deficiency of dhh1 ∆ and lsm6 ∆ mutants are rescued by deletion of the self-splicing mitochondrial introns (Luban et al. 2005).