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The gene growth differentiate factor 5 (GDF5) has been implicated in skeletal development and joint morphogenesis in humans and mice.
Diminished cortical filamentous actin (F-actin) has been implicated in skeletal muscle insulin resistance, yet the mechanism(s) is unknown.
Of the seven different known type I receptors, BMPR-IA and BMPR-IB have been implicated in skeletal patterning.
Many of these hormones have been implicated in skeletal metabolism and OA, which makes NCOA3 a compelling causal candidate gene.
Transcription factor SOX4 has been implicated in skeletal myoblast differentiation through the regulation of Cald1 gene expression; however, the detailed molecular mechanism underlying this process is largely unknown.
32 Finally, rs5009270 resides near IFDRD1 which codes an interferon-related developmental regulator and has been implicated in skeletal muscle regeneration.
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RHBDF1 has recently been implicated in signalling from the epidermal growth factor receptor [ 46] that is implicated in skeletal development, as well as in autophagy [ 47].
A second illustrative pathway features GLUT-4 (glucose transporter type 4) and interleukin-6, both of which are implicated in skeletal muscle metabolism [ 36].
Several mutations of its gene (NOG) have been previously reported to be implicated in skeletal anomalies, such as proximal symphalangism, tarsal/carpal coalition syndrome, and brachydactyly type B (BDB) [ 29, 30].
Recently, DDR2 function has been implicated in human skeletal growth.
PLA2G4A has previously been implicated in broad spectrum skeletal muscle myopathies in broiler chickens [ 27].
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been detected in skeletal
been shown in skeletal
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