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Several genes have been implicated in severe early-onset epilepsy.
Lack of the human cathelicidin LL-37 has been implicated in severe periodontitis, whilst high salivary levels of LL-37 seem to increase caries resistance.
Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in severe pre-eclampsia (SPE) and is characterized by the activation of three signaling pathways: PKR-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (and6), and inositol-requiring 1 (Ire1).
This has also been implicated in severe emotional dysregulation [ 21, 22].
ADE of dengue has long been implicated in severe, usually secondary, DEN infections.
Hg has been implicated in severe but localized poisonings (Ekino et al. 2007).
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Whether it's disgraceful labour practices, disregard for local communities or dealings with offshore detention centres, Australian businesses continue to be implicated in severe abuses that contravene international human rights law.
Objective: The "red complex," composed of Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola, is implicated in severe forms of periodontal diseases.
Lack of a visible phenotype in mtm mutants and the level of endogenous PtdIns5P not significantly lower than in fresh wild type cells suggest that the AtMTM1 function is not essential for the cellular homeostasis in non-stressed cells, in stark contrast with humans where myotubularin deficiency is implicated in severe muscle dystrophy, neuronal diseases, and leukemia [1], [3], [31].
This gene has been previously shown to be implicated in severe asthma (Wenzel et al., 2007).
Disruptions in the forebrain hem system may be implicated in severe brain malformations such as holoprosencephaly.
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