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Signaling through the polymodal cation channel Transient Receptor Potential Vanilloid 4 (TRPV4) has been implicated in retinal neuronal degeneration.
One of the GCAPS, GCAP1, has been implicated in retinal degenerative diseases.
Proinflammatory cytokines including TNF- α, interleukin- (IL-) 1 β, and IL-6 have been implicated in retinal inflammation under diabetic conditions.
Regarding the seven netrin-1 receptors, our study showed that UNC5B and/or neogenin may have been implicated in retinal neovascularization.
Since inflammatory events have been implicated in retinal pathologies including age related macular degeneration (AMD) [ 91], H2O2 signaling may not only be neuroprotective via regulation of Lif expression but may affect the outcome of retinal degenerative diseases on several levels.
Inactivation of DICER1, an RNase III endonuclease that is essential for the production and function of mature miRNAs, has been implicated in retinal degeneration [ 76], and Alu RNA toxicity has been suggested to a play a role in AMD [ 77].
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Several mechanisms are implicated in retinal ganglion cell death in glaucoma including direct effect on retinal ganglion cells, activation of glial cells to produce cytotoxic molecules like TNFα, alteration in trabecular meshwork, autoimmunity etc [39], [40].
This radial shape provides the potential to be implicated in retinal development, function and integrity, and to exert many functions that require an intimate interaction with neurons and synapses [1].
Several of the protein subunits making up these channels are implicated in retinal disease.
Disruption of this normal polarized configuration of RPE cells is implicated in retinal disease (Nasonkin et al., 2013).
Here, we evaluated whether caspase-14 is implicated in retinal pigment epithelial cells (RPE) dysfunction under hyperglycemia.
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