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Both phosphatases have been implicated in restricting PIP3 to the leading edge and preventing the lateral diffusion [70], [71].
Nevertheless, RNAi has been implicated in restricting the replication of various mammalian viruses including HBV [2], [3], influenza A [4], and HIV-1 [5], among others.
Alterations in the nuclear matrix have been implicated in restricting cellular proliferation in mortal human fibroblasts [ 10].
APOBEC3 proteins have also been implicated in restricting a large number of DNA-based parasites, including cancer-associated viruses Epstein-Barr virus, hepatitis B virus, human papilloma virus, and human T-lymphotropic virus-1 [ 18, 25, 28].
Since spreading cell death in older atg mutants is first macroscopically visible several days post infection, and as NPR1 has previously been implicated in restricting HR cell death triggered by RPM1,, we investigated the importance of NPR1-dependent HR cell death.
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Hypertension on the other hand has been implicated in the aetiology of asymmetrically restricted babies in earlier studies.
Whilst SOCE has been implicated in HPV, the evidence is largely restricted to Phase 1 and studies in isolated PASMCs.
Conversely, many luminal-specific miRNAs have been implicated in targeting transcription factors that are restricted to basal cells in the mammary gland such as Snai2 and Trp63 [ 11, 12].
The proteoglycan agrin has been implicated in the polarized distribution of AQP4, specifically restricting OAPs to end-feet membranes (Warth et al., 2004; Noell et al., 2007, 2009).
Lithium-ion batteries are popular, but have been implicated in fires on board planes, and their transport is restricted.
In addition to the cardiovascular miRs reviewed above, a number of other miRs, not restricted to cardiovascular system have also been implicated in the pathophysiology of DHD.
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