Sentence examples for been implicated in responsiveness from inspiring English sources

The Wnt and insulin signalling pathways (Spitzner et al, 2010), VEGF and EGFR levels (Toiyama et al, 2010) as well as the apoptotic index (Rodel et al, 2002) have all been implicated in responsiveness.

Here, in a series of 48 breast cancer patients with HER2 gene amplification we retrospectively investigated numerous additional biomolecular parameters to have potential impact on the course of disease under Herceptin™ treatment (prognostic value) and to be implicated in responsiveness to Herceptin™ treatment (predictive value).

Several of these genes have been implicated in hormone responsiveness and disease progression.

From a more general point of view, the gene encoding OXTR has been implicated in the responsiveness to social support as a buffer against stress [ 26].

SOCS1 has been implicated in hypo-responsiveness to cytokines such as IFN-γ after the exposure of macrophages to LPS [ 61].

The latter has been implicated in the abnormal vascular responsiveness to endothelin-1 and angiotensin II in diabetic-hypertensive rats.

Recently, Prkce has been implicated in the loss of insulin secretory responsiveness during the development of type 2 diabetes [ 43], while others highlighted its role in the pathomechanism of drug dependence and addiction [ 44].

Thus specific IgG blocking antibodies have been implicated in the generation of early clinical non-responsiveness [5] [6] and may be induced through local and systemic IL-10 derived from regulatory T cells and other cells [5].

Diverse mechanisms have been implicated in the development of anergy associated to E3 ligases, among these, the setting for TCR responsiveness and repression of cytokine transcription are best well characterized.

Conversely, DNA hypomethylation has been implicated in over expression of myeloid differentiation factor (MD -2 in huMD -2ECs leading to humanr responsIECsess to leadingosure [ 2].

The peptide adrenomedullin (ADM) has been implicated in the development of septic shock: It is important in initiating the hyperdynamic response during the early stage of sepsis, and the reduced vascular responsiveness to ADM is associated with the transition from the hyperdynamic phase to the hypodynamic phase during the progression of sepsis [11 14].