In yeast, Ras small GTPases have been implicated in regulation of the cAMP pathway and suggested to regulate adenylate cyclase [ 66].
Extracellular-signal-regulated kinase (ERK -mediated signaling has bERK -mediatedd in regulation of signalingplasticity.
Importantly, orexin, a neurotransmitter that regulates arousal, wakefulness, and appetite, has recently been implicated in regulation of glucose metabolism, leptin sensitivity, and spontaneous physical activity (31).
It has also been proposed that Sir2 in the fat body plays a role in regulating fat storage and mobilization as Sir2 / Sirt1 has been implicated in regulation of fat metabolism in flies and mammals.
In particular, proteins that regulate mitochondrial dynamics, such as Mfn2 and Drp1 have been implicated in regulation of mitochondrial steps of apoptosis in mammalian cells.
MED14 has been implicated in regulation of lipid homeostasis.
Among the 11 rice CKXs, CKX2 has been implicated in regulation of rice grain yield.
Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in regulation of both the Hippo-Yap and Rac1-Pak1 pathways.
Trak1 is a ubiquitously expressed protein that has been implicated in regulation of mitochondrial transport (van Spronsen et al., 2013; Stowers et al., 2002; Brickley and Stephenson, 2011) and endosome-to-lysosome trafficking (Webber et al., 2008).
ERK pathway has been implicated in regulation of neuronal function, cell survival and in learning and memory [52].
The C-terminal domain (CTD) of the enzyme has the most diversity, and has been implicated in regulation.
