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Dietary substances such as vitamin B, caffeine, and alcohol also have been implicated in reducing the risk of Alzheimer disease.
Soy isoflavones have been implicated in reducing the overall incidence of breast and prostate cancers in Asian countries.
Thus far, AnxA1 has been implicated in reducing granulocyte-tissue infiltration by blocking neutrophil-endothelial interactions and accelerating neutrophil apoptosis.
Orally administered curcuminoids have been implicated in reducing Aβ plaque burden and the amount of soluble Aβ in Alzheimer transgenic mice [ 20].
Several checkpoint-related proteins have been implicated in reducing the frequency of HR, that otherwise could lead to destabilization of replication forks and generation of toxic HR intermediates [34,35].
38 More of our tenofovir-treated cohort took oral corticosteroids, were chronic cigarette smokers, and had truncal obesity or wasting syndrome, all of which have been implicated in reducing bone mineral density.
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We observed deterioration of trabecular architecture, decreased bone mass, and decreased cortical thickness, all of which have been implicated in reduced bone strength and increased fracture incidence in humans (Barth et al. 1992; Wachter et al. 2002).
This is of particular importance since expression of MDR-1 and its encoding protein P-gp have been implicated in reduced drug up-take, thereby mediating resistance to chemotherapy [ 36, 37].
While Y4 agonism with PP in the brainstem is implicated in reducing food intake via indirect effects on gastrointestinal function, the hypothalamus also appears to be involved.
7 8 NSAIDs are implicated in reducing collagen synthesis and hydroxyproline deposition during the healing process.
This result is important evidence that DHA is able to modulate the AMPK pathway, which is implicated in reducing cell proliferation and in regulation of cell metabolism.
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